1: Naming of HDMI or DisplayPort devices connected to the graphics card changed and no longer is suffixed with a different number.
2: In VoiceMeeter, I now am only able to select *one* of my monitors as a Hardware Out. Attempting to specify the second one has no effect and does not change the hardware out at all.
So, now I can only route audio to one monitor, whereas before I was able to interact with each monitor independently. This is what I currently see in VoiceMeeter Banana:

The second device named "C27F591" cannot be selected *at all*.
For reference, this is the Playback Options menu and what it lists:

Note the two C27F591 devices - only one is being locked by VoiceMeeter, ever. Prior to the Nvidia update, one of these was typically named C27F591-0, and the other named C27F591-4 or C27F591-8.
I currently use the following setup:
EVGA GTX 1070 [via displayport x2] -> DisplayPort KVM [via displayport x2] -> Samsung C27F591 [x2]
I've also tried taking the DisplayPort KVM out of the picture in troubleshooting to confirm that it is not the issue, and have verified that it does not affect the problem.
Wild guess: something is probably going by the device name for selecting the hardware out?