Every week I use VMB to co-produce a podcast/Hangout (http://vuc.me) We're a bit involved in how we do it. We have participants all around Europe & North America.
The foundation of the show is a Hangout-On-Air. I interconnect the HOA to a telephone conference bridge that's globally accessible. We have local access numbers in 40 countries. Most people who participate via telephone do so by direct SIP connection. People who participate via telephone are fully interactive with the group in the HOA.
I use VoiceMeeter Banana to provide the audio interconnect between the HOA, a SIP soft phone (Bria 4) and my DECT headset. I also use it to play a prerecorded show opening.
This arrangement generally works great, with one exception. Chrome on my desktop routinely chokes on the audio from VMB. When it does the audience reports that I sound robotic. They say that I sound "Cylon-like."
I've tried a dozen different tweaks over the past year, but I cannot get this problem to go away.
At first I thought there might be a problem with my Sennheiser USB/DECT headset, but I found that playback of a WAV files in VMB is similarly robotic when in the fault state. So it seems that ALL sounds from VMB to the Hangout is impacted.
The definitive solution is to close Chrome completely. Restart it and rejoin the Hangout. And hope that it doesn't happen again.
Is there anything that you can suggest I try? Perhaps a way to gather some more detailed info? Any known issues with interacting with Chrome's audio engine?
Here's a screen shot of my VMB settings.

Routing is a follows:
Input #1 = Sennheiser DW Pro 2 USB headset
- to physical output #2 (a VB-Cable which feeds Bria input to conference bridge)
- to virtual output #1 (audio feed to hangout)
Input #2 = Not used
Input #3 = VB Cable B (sound from Bria soft phone)
- to physical output #1 (Sennheiser DW Pro 2 USB headset)
- to virtual output #1 (audio feed to hangout)
Virtual Input #1 = PC/sound from Hangout
- to physical output #1 (Sennheiser DW Pro 2 USB headset)
- to physical output #2 (a VB-Cable which feeds Bria input to conference bridge)
I have found that my headset works best using MME mode. Since everything we do is wideband telephony (HDVoice), the difference in latency & quality is not an issue.
Today when the problem occurred I tried swapping all use of Virtual Output #1 to Virtual Output #2. Then in the Hangout app I selected the "AUX" output as the source. That overcame the issue without resorting to restarting Chrome.
I wish I could determine exactly what goes awry.